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BAG3, a co-molecule chaperone protein of HSP70, which belongs to stress, survivin and can be induced in stress.BAG3 protein is involved in a series of physiology, including value-added, apoptosis, adhesion, metastasis and virus addiction, Pathology process.

BAG gene has been implicated in age related neurodegenerative diseases such as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively. It has also been shown to be the cause of familial dilated cardiomyopathy.

In muscle cells, BAG3 cooperates with the molecular chaperones Hsc70 and HspB8 to induce the degradation of mechanically damaged cytoskeleton components in lysosomes. This process is called chaperone-assisted selective autophagy (CASA) and is essential for maintaining muscle activity in flies, mice and men.

BAG3 is able to stimulate the expression of cytoskeleton proteins in response to mechanical tension by activating the transcription regulators YAP1 and WWTR1.BAG3 balances protein synthesis and protein degradation under mechanical stress.